Mesenchymal stem cell therapy could beat COVID-19

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16

JUL 2020

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Mesenchymal Stem cell therapy could beat COVID-19

By: admin | Uncategorized

In recent times under the current COVID-19 crisis scenario, severe respiratory consequences of the COVID-19 pandemic have prompted an urgent need for novel therapies to address the raising concerns.

Preventing & reversing the cytokine stroma may be the key to save the patients with severe COVID-19 pneumonia. Research in the field of Stem Cells across the globe have found Mesenchymal Stem Cells (MSCs) to possess a comprehensive powerful immunomodulatory function. The clinical outcomes, as well as changes of inflammatory & immune function levels and adverse effects of patients, were assessed for 14 days after injecting Mesenchymal Stem Cells (Dental Stem cells). Mesenchymal Stem Cells derived from Dental Pulp could cure or significantly improve the functional outcomes of patients without observed adverse effects.

The pulmonary function and symptoms of the patients showed significant improvements in 2 days after Mesenchymal Stem Cells transplantation. Most severe patients recovered and got discharged in 10 days of their treatment using these Stem Cell therapies following a rapid recovery. After treatment, the peripheral lymphocytes increased, the C-reactive protein decreased, and the over-activated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. Also, a group of CD14+ CD11c+ CD11bmid regulatory DC cell populations dramatically increased. Meanwhile, the level of TNF-α significantly decreased, while IL-10 increased in the Mesenchymal Stem Cell treatment group compared to the placebo control group.

Furthermore, the gene expression profile showed Mesenchymal Stem Cells were ACE2- and TMPRSS2- which indicated Mesenchymal stem cells (Dental pulp stem cells) are free from COVID-19 infection. Thus, the intravenous transplantation of Mesenchymal stem cells was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe conditions. MSCs (Mesenchymal Stem Cells) also showed great potential in patients suffering from Acute Lung Injury (ALI) & Acute Respiratory Distress Syndrome (ARDS).

Mesenchymal stem cell sources:

Bone marrow, Cord Tissue, Adipose Tissue & Dental pulp of the deciduous tooth.


Dental Stem Cell Banking:

Parents who have missed the opportunity of banking Mesenchymal Stem Cells of their child at birth can now bank these stem cells from the milk teeth between 5-11 years of their age. This process is also known as Tooth Stem Cell Banking or Milk Tooth Stem Cell Banking or Children Tooth Stem Cell Banking. Any milk tooth which is healthy without any cavities is suitable for Dental Stem Cell preservation.


Process of Dental Stem Cell Banking:

Parents who wish to preserve their children’s dental stem cells (Milk teeth banking) are required to initially do the enrolment process with the company when the child’s age is between 5-11 years. Mothercell is the biggest dental stem cell bank in the world with the best in class banking practices following the global standards-based at Hyderabad, India. Mothercell is a pioneer with its superior cutting edge technology and state of the art stem cell laboratory amongst other Milk Teeth Banks in India. After enrolling with Mothercell, the company will decide the tooth collection date and the number of milk teeth needs to be collected for dental stem cell banking purposes in consultation with the parents. One or two identified milk teeth will be collected by a dentist and will be placed in a dedicated Mothercell Kit Box which can maintain the ambient temperatures for 48-72 hours. The whole process of stem cell processing and stem cell cryopreservation will take approximately 55-60 days from the date of tooth collection, and the final dental stem cell preservation report will be issued after the successful stem cell storage.

Benefits of Dental Stem Cell Banking:

Mesenchymal stem cells extracted from dental pulp have a remarkable multi-point ability and they can be differentiated into any organ/tissue related cells in our body. Parents who have preserved these dental pulp stem cells of their children have an opportunity to address any organ/tissue related degenerative conditions in the future. Dental pulp stem cell banking is one of the best options to safeguard the future health of children. It truly is a life-saving concept & with a rise in new life-threatening disorders like COVID-19 or Coronavirus infections, Dental Stem Cells have been proven to be a savior again in the healthcare domain.

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